In the WHO classification of 2010, NETs were defined as neuroendocrine neoplasms and were classified as NET G1, NET G2, NEC (large cell or small cell type), mixed adenoneuroendocrine carcinoma (MANEC), hyperplastic, and preneoplastic lesions, by the Ki-67 index [1–4]. The gene discussed is MKI67; the disease is digestive system mixed adenoneuroendocrine carcinoma.