EIF4EBP1 and neoplasm: Dysregulated expression as well as increased phosphorylation of 4E-BPs in cancer also results in poor patient prognosis and the loss of 4E-BP1 with the resulting activation of cap dependent translation promotes cell-cycle progression and cell proliferation in culture [136, 137] whereas overexpression of constitutively active 4E-BP1 suppresses tumor growth in vivo [138, 139].