AZD8055 potently (IC < 1 nM) inhibits the rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1, resulting in significant inhibition of cap dependent translation. In vitro, AZD8055 effectively inhibits cell proliferation and induces autophagy and, in vivo, AZD8055 inhibits tumor growth [158]. Here, EIF4EBP1 is linked to neoplasm.