Donor mbl2 genotype was the strongest determinant of post-transplant circulating MBL levels, a not surprising finding considering that this pattern recognition molecule is produced primarily by the liver.39 MBL deficiency has been also linked to the development of sepsis in kidney or pancreas–kidney transplant recipients14, 40 or CMV infection after discontinuing valganciclovir prophylaxis.41 More studies are needed to determine the optimal cutoff levels and timing for the monitoring of this biomarker. This evidence concerns the gene MBL2 and mannose-binding lectin deficiency.