Esophageal biopsies with isotype-matched IgG (primary anti-CXCL16 antibody is replaced by rabbit IgG isotype matched), the isotype-matched IgG antibody did not show any positive staining in the mucosa of normal or EoE patients (Figures 4e and f). This evidence concerns the gene CXCL16 and eosinophilic esophagitis.