Uncaria tomentosa extract did not reduce the cytotoxic effects of chemotherapy. In vitro, the concomitant use of Uncaria tomentosa and oxaliplatin resulted in increased levels of apoptosis in adenocarcinoma cells via an increase in the activities of caspases 8, 3, and 1 and decreased ERCC1 mRNA levels. This evidence concerns the gene CASP8 and adenocarcinoma.