There is no evidence that empirical hormonal therapies such as human menopausal gonadotrophin (HMG), human chorionic gonadotrophin (HCG), androgen, antioestrogens (clomiphene and tamoxifen), prolactin inhibitors (bromocriptine), and steroids improve male fertility except in certain conditions such as low testosterone level, hypogonadism, and hyperprolactinaemia [4]. This evidence concerns the gene PRL and hyperprolactinemia.