CREB1 and Anxiety: Mice with early onset of Creb ablation throughout the nervous system (CrebNesCre mice) and CrebαΔ knock-out mice with a hypomorphic allele and highly reduced CREB levels show in accordance with the present data higher anxiety levels in elevated zero maze, elevated plus maze Dark-Light Box and openfield (Valverde et al., 2004; Gur et al., 2007).