The cells that comprise LAM and TSC tumors reflect many features of hyper-active mTOR signaling: abnormally large or “giant” cells, altered morphology, aberrant migration, abnormal proliferation, increased cell survival and reduced autophagy are common features of many lesions (Crino, 2004; Crino and Tsai, 2012; Henske and McCormack, 2012). Here, MTOR is linked to tuberous sclerosis.