Among DC subsets, it should be emphasized the role of tumor-infiltrating plasmacytoid DCs (pDCs) and CD8α+ DCs lineage, being the first often related to T cell tolerance, while the latter is in fact particularly efficient in the cross-presentation of antigens via MHCI pathways and thus in cytotoxic T-cell immunity (Hildner et al., 2008; Fuertes et al., 2011; Watkins et al., 2011). Here, CD8A is linked to neoplasm.