The role played by CAFs in the development and progression of breast cancer relies on their ability to produce stromal ECM (extracellular matrix) proteins and secrete many growth factors and hormones, including insulin like growth factor (IGF)-I, IGF-II, epidermal growth factor (EGF), transforming growth factor (TGF)-α, TGF-β (3). This evidence concerns the gene EGF and breast carcinoma.