For instance, four patient samples had ICD9 code 233.1 (carcinoma in situ) (Table 1) and three of them (samples #109, #110, and #116) had S100A7 genes up-regulated and another set (samples #110, #111, and #116) had KLK6 up-regulated in normal to LGSIL pairs. Here, S100A7 is linked to in situ carcinoma.