Inhaled diphtheria vaccine is in early stages of development, but a dry powder formulation of diphtheria CRM-197 antigen with PLGA as an adjuvant, administered using the Insufflator®, resulted in lower IgG in the sera and higher IgA in the BAL of guinea pigs, compared to intramuscular injection [60]. The gene discussed is CD79A; the disease is diphtheria.