INS and diabetes mellitus: Drugs that have been tested include opioids for pre- and post-operative analgesia, dihydroergotamine (DHE) for acute treatment of migraine, interferon β to treat multiple sclerosis, leuprolide acetate to treat prostatic cancer, infertility and post-menopausal breast cancer, calcitonin to treat postmenopausal osteoporosis, growth hormone releasing factor to treat pituitary dwarfism and insulin to treat diabetes.