AUTS2 and Addictive alcohol use: The first GWAS on alcohol addiction (Treutlein et al. 2009) and alcohol consumption (Schumann et al. 2011; Stacey et al. 2012) yielded several genome-wide findings, especially in the alcohol dehydrogenease (ADH) cluster (Frank et al. 2012) and AUTS2 (Schumann et al. 2011) and were replicated in independent studies (Biernacka et al. 2013 (ADH, Kapoor et al. 2013 (AUTS2)) (Figure 1).