Hyperphosphorylation of tau was previously shown in genetic mouse models overexpressing mutant human α-synuclein (Wills et al. 2011) or models expressing WT α-synuclein predominantly in the cortex (Haggerty et al. 2011; Kaul et al. 2011) which reproduce Lewy body disease more closely than PD. This evidence concerns the gene MAPT and Lewy body dementia.