MAPT and synucleinopathy: Even though a genetic lack of tau did not improve motor deficits in mice overexpressing α-synuclein under the Thy-1 promoter (Thy1-aSyn mice) (Morris et al. 2011), in a cellular model of synucleinopathy, tau enhanced aggregation and toxicity of α-synuclein (Badiola et al. 2011).