Moreover, the neuroprotective effect of galantamine and donepezil (approved drugs for the symptomatic treatment of Alzheimer’s disease) has been demonstrated to be mediated by the stimulation of α7 nAChR in rat primary neurons (Takada-Takatori et al. 2006a,b; Shen et al. 2010). This evidence concerns the gene CHRNA7 and Alzheimer disease.