NOS2 and uveitis: In addition to the above experiments, in the rat model of uveitis induced by footpad injection of endotoxin, treatment with XG-102 by either the IV or the intravitreal route just before endotoxin administration significantly decreased the uveitis clinical scores, the numbers of infiltrating inflammatory cells and the inducible nitric oxide synthase expression in the eye as compared to vehicle (Touchard et al. 2010).