MAPK8 and inflammatory bowel disease: In the hepatobiliary/digestive tract, JNK activation has been observed in inflammatory bowel disease (IBD), colitis, hepatic injury, liver ischemia, reperfusion injury, acute liver injury, chronic hepatitis C virus infection, and nonalcoholic fatty liver disease (Relja et al. 2009; Han et al. 2010; Reinecke et al. 2012; Sabapathy 2012; Seki et al. 2012).