SNPs in or near JAK2, CNOT6, MAML1, CD40, IL-4R, and IL-5RA genes were associated with allergic sensitization and SNPs in or near JAK1, JAK3, IL5RA, FCER1A, and ADAM33 genes were associated with cockroach sensitization. The gene discussed is JAK1; the disease is hypersensitivity reaction disease.