IFIH1 and systemic lupus erythematosus: This polymorphism appears to be gain-of-function in nature, being associated with increased IFIH1 mRNA expression (Downes et al., 2010), increased sensitivity to type I IFN and increased IFN-induced gene expression in circulating blood cells from SLE patients (Robinson et al., 2011), and modulation of inflammation- and apoptosis-related gene expression (Molineros et al., 2013).