IFIH1 and systemic lupus erythematosus: This A946T polymorphism in IFIH1 was identified in case-control genetic studies of SLE (Harley et al., 2008; Gateva et al., 2009), and interestingly this polymorphism was the major finding in a recent admixture-mapping genetic screen to identify genes associated with SLE in African-Americans (Molineros et al., 2013), supporting relevance of this polymorphism across multiple ancestral backgrounds.