In conclusion, numerous evidences suggest that some intracellular bacterial and protozoan pathogens responsible for chronic (Mycobacteria, Brucella, Leishmania, and Toxoplasma) but also acute (Francisella and Listeria) infection actively manipulate STAT6-PPARγ/δ pathways to avoid M1 polarization of macrophages and/or benefit from a nutrient rich environment associated to lipid oxidation metabolism. This evidence concerns the gene STAT6 and infection.