DISC1 and schizophrenia: Based upon this expression pattern and given the potential role of adult neurogenesis in schizophrenia and other neuropsychiatric diseases, a number of studies have suggested a potentially important role for DISC1 in regulating microcircuit architecture through its regulation of neurogenesis in the dentate gyrus (Ghashghaei et al., 2006; Reif et al., 2006, 2007; Mao et al., 2009; Ming and Song, 2009; Inta et al., 2011; Kim et al., 2012).