Using a genetic mouse model employing a DISC1 mutation that accurately recapitulates the consequences of the human chromosomal translocation, a comprehensive battery of behavioral analyses has revealed a pattern of cognitive deficits in these mice that appears to reflect cognitive deficits found in schizophrenia (Koike et al., 2006; Kvajo et al., 2008). Here, DISC1 is linked to schizophrenia.