Earlier, mRNA, Western blotting and immunohistochemical studies have shown that VIP/PACAP receptors are expressed in the great majority of the most frequently occurring human tumours, including breast, ovarian, prostate, pancreas and colon carcinomas, insulinoma, carcinoid, glioblastoma, meningioma, pituitary adenoma and pheochromocytoma (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14). This evidence concerns the gene VIP and neoplasm.