Moreover, we found tumor-specific downregulation of ZNF677 expression also in breast carcinomas, colon and rectum adenocarcinomas, renal clear cell carcinomas, head and neck squamous cell carcinomas and endometrioid carcinomas suggesting that ZNF677 may play an important role also in the pathogenesis of several other malignant diseases. Here, ZNF677 is linked to rectum adenocarcinoma.