This study combined with another report showing IFN-γ and LPS can synergistically induce Duox2/DuoxA2 expression and ROS production in human pancreatic cancer cells [6], strongly supports that NOXs are the major source of ROS production during inflammatory stimuli and act as a critical modulator of the inflammatory response in the context of tumorigenesis. This evidence concerns the gene DUOX2 and familial pancreatic carcinoma.