TP53 and neoplasm: In their study, Vassilev et al. [6] showed a potent antitumor activity of Nutlins on wild-type p53 tumor cell lines, such as HCT116, RKO and SJSA-1 cells, whereas only a marginal effect on mutant p53 cell lines (such as SW 480, MDA-MB-435, PC3) was observed.