PNPLA3 and cryohydrocytosis: Our results showing an association between PNPLA3 non-CC genotype and risk of clinical deterioration in age, sex, and race-adjusted analysis is supported by a study showing an association between the PNPLA3 C>G polymorphism and fibrosis progression in CHC [14] and a meta-analysis showing an association between this polymorphism and hepatocarcinogenesis in subjects of European descent [16].