Of note in the present study, the immunohistochemical analysis revealed significantly higher expression of NF-κB and CXCR4 in neuroblastoma tissues when compared to ganglioneuroma tissues, which further supports the increasing data that NF-κB and CXCR4 are abnormally expressed in neuroblastoma cells. The gene discussed is CXCR4; the disease is neuroblastoma.