The activation of NF-κB induces the expression of various molecules, including cyclooxygenase-2, matrix metallopeptidase-9 and adhesion molecules, such as intracellular adhesion molecule 1, vascular cell adhesion molecule 1 and endothelial-leukocyte adhesion molecule 1, all of which have been linked with cancer cell invasion and metastasis (34). The gene discussed is NFKB1; the disease is cancer.