The expression rate of CXCR4 positive was 70.0% (56/80) in the neuroblastoma group, which was significantly higher than the rate of 25.0% (3/12) in the ganglioneuroma group, and the difference between the two groups was statistically significant (P=0.0008) (Fig. 1, Table II). This evidence concerns the gene CXCR4 and neuroblastoma.