TGFB1 and Cirrhosis: However, in the present study's ESM group, Tgfβ3, not Tgfβ1, was differentially down-regulated, the relevance of which is supported by our previous finding that the expression of Tgfβ3 was 2.6-fold higher than the Tgfβ1 expression in a CCl4-induced rat cirrhosis model for 19 wks2.