TGFB1 and Hepatic fibrosis: In the present study, to investigate the bioavailability of ESM in the process of hepatic fibrosis, we utilized a stimulation model of TGFβ1 (which is known as a key regulator in HSC activity in vitro) by using soluble hydrolyzed products of ESM, and we used a CCl4-induced hepatic injury model in vivo that causes oxidative stress.