Since the tumor suppressive actions of the FoxO3 are well documented (Renault et al., 2011; Qi et al., 2011a, b; Karube et al., 2011), our findings imply that massive inactivation of FoxO3 by Thr32 phosphorylation may either initiate a progressive cancer-prone condition or have a pro-metastatic role to promote tumor progression in liver cancer. Here, FOXO3 is linked to liver cancer.