It is widely accepted and recommended that the most efficient precaution for prevention of perinatal HBV transmission is screening pregnant women for HBsAg and the immediate administration of one infant dose of hepatitis B immune globulin (HBIG) along with the first hepatitis B vaccine dose within 12 hours after birth, followed by the second and the third vaccine dose at 1 and 6 month of age [55], [56], [57], [58], [59]. The gene discussed is PPIB; the disease is hepatitis A virus infection.