[1], [27] The involvement of different chemokines and chemokine receptors has been explored for more than a decade and yet the extent of their role in AMD is not fully understood. The chemokine receptors CCR2 and CX3CR1 have been implicated in the development of AMD. Especially murine models have shown that CCR2 and CX3CR1 and their ligands CCL2 and CX3CL1 are involved in drusen formation and RPE changes seen in the early stages of AMD. [6], [7], [28], [29]. The gene discussed is CX3CR1; the disease is age-related macular degeneration.