As expected, 14 days after the inoculation of tumor cells, the band density of Nav1.8 protein expressed on the cell membrane increased markedly in MRMT-1-treated rats (1.45±0.06, n = 6) compared to PBS-treated rats (0.87±0.07, n = 6) (P<0.001, two-way ANOVA, Fig. 3B). The gene discussed is SCN10A; the disease is neoplasm.