ANGPT1 and preeclampsia: On the other hand, some predicted targets of C19MC microRNAs, that were subject of interest in the current study, were shown previously to be upregulated in first trimester maternal plasma/serum samples derived from patients with preeclampsia, SGA, preterm delivery, miscarriage or stillbirth (e.g. soluble Flt-1, Ang-1/Ang-2 ratio) (Table 4, S1, S4 Tables).