The aim of this study is to establish a mini profile with three different cancer lines (the Kras mutant cell lines: non-small cell lung carcinoma A549 and human colon carcinoma LoVo, and the Kras wild-type cell line: human breast cancer SK-BR-3) to quantitatively and functionally evaluate the apoptotic effect with different doses of propofol, and thereby determine whether propofol might be advantageous as an anesthetic for surgeries of certain cancers. The gene discussed is KRAS; the disease is breast carcinoma.