In total, 12 of the 65 reported T2D GWAS loci are significantly differentially methylated (FDR 25%), and these include well-documented T2D loci such as those near IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2) and THADA (thyroid adenoma-associated gene). The gene discussed is IGF2BP2; the disease is Thyroid adenoma.