In addition, we found that endothelial Egr-1 expression can also be induced by EVs from other human cancer cells (HCT116 colorectal carcinoma, A549 lung adenocarcinoma, PC3 prostate carcinoma, HT1080 fibrosarcoma, and SH-SY5Y neuroblastoma) but not by normal human bronchial epithelial BEAS-2B cell-derived EVs. The gene discussed is EGR1; the disease is colorectal carcinoma.