Moreover, EVs from other human cancer cells (HCT116 colorectal carcinoma, A549 lung adenocarcinoma, HT1080 fibrosarcoma, PC3 prostate carcinoma, and SH-SY5Y neuroblastoma) also induced Egr-1 mRNA expression in human endothelial cells, whereas EVs from normal human bronchial epithelial cells (BEAS-2B) did not (Fig. 2B). Here, EGR1 is linked to colorectal carcinoma.