However, when used to infect human and murine non-hematopoietic cell lines derived from various tissues (human embryonyc kidney cells HEK293T, mouse mesenchymal stromal cells MS-5, mouse embryonic fibroblasts NIH3T3, and human medulloblastoma cells DAOY) UMG-LV6 promoted in all cases strong expression of both EGFP (Fig. 8A, 8B) and of transgene (Fig. 8B), comparable to those induced by UMG-LV11, suggesting that the functional interaction with the adjacent UBC promoter may overcome the tissue-specificity of the WASP regulatory element. Here, WAS is linked to medulloblastoma.