RBMX gene, also known as HnRNP G, is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family and can collaborate with hTra2-beta1 (human transformer-2-beta1) as sequence-specific transacting factors to exert antagonistic effects on alternative splicing which is recognized as a pivotal mechanism in regulation of gene expression and associated to tumorigenesis and metastasis of a wide variety of human cancers [26]. This evidence concerns the gene RBMX and cancer.