Taken together, our gene expression profile that show a significant up-regulated result of CFTR in more metastasis and chemoresistant ovarian cancer cell lines are consistent with previous findings, a further research on the mechanism of CFTR on ovarian cancer or selective inhibition of CFTR or its pathway may give a insight in therapeutic effects against metastatic and chemoresistant of ovarian cancer. The gene discussed is CFTR; the disease is ovarian cancer.