XIAP and chondrosarcoma: In addition, siBMPR2 promoted the inhibition of XIAP, and enhanced the expression of cleaved PARP and caspase-3 in SW1353 cells transfected with siXIAP, indicating that when cells were transfected with both siXIAP and siBMPR2, siRNAs significantly accelerated the apoptosis of chondrosarcoma cells as compared with when transfected with siXIAP or siBMPR2 alone (Figure 5f).