TP53 and chondrosarcoma: However, siXIAP promoted autophagy in chondrosarcoma cells transfected with siBMPR2, and when cells were transfected with both siXIAP and siBMPR2, siRNAs significantly increased the expression of Mdm2 and LC3-II, and decreased the expression of p53 and p62, compared with when transfected with siBMPR2 alone.