PIK3CA-mutations in CRC limit therapeutic options and are associated with poor prognosis.3 Isogenic HCT116 cell lines expressing solely a wild-type or mutant (H1047R) PIK3CA allele exhibited a constitutively activated PI3K/Akt-pathway, high-level resistance against TRAIL-induced cell death10 and increased invasiveness in vitro and in vivo. This evidence concerns the gene PIK3CA and colorectal carcinoma.