CAMKK2 and Alzheimer disease: Most recently, Ca2+ and CaMKKβ-dependent AMPK activation by Aβ was confirmed in a study which also demonstrated that activation of the kinase led to a loss of dendritic spines (an early feature of AD) and also to Tau phosphorylation.59 Our data indicate that Aβ activates AMPK in SH-SY5Y cells (Figure 7).