DHTKD1 and cancer: Cytotoxic T cells directed against antigens that are endogenously expressed and presented by cancer cells are critically involved in antigen-specific cancer immunotherapy.17 In order to study mechanisms modulating the effector phase of antigen-specific cellular immunotherapy we have established experimental systems based on St42 mice, which express a transgenic T-cell receptor (TCR) recognizing the cognate peptide SGPSNTPPEI from the adenovirus E1A protein (amino acids 234–243) when presented by H2-Db (Toes et al.18).