The induction and release of interferons by T cells is triggered by antigen-specific TCR activation.45 It is crucially involved in the control if virally infected host cells.46, 47 Elaborate studies support a role for interferon-gamma in T-cell-mediated tumor elimination via direct and indirect mechanisms.48, 49, 50 In our experimental systems COX-2 failed to mediate cross-resistance to generic cytotoxic insults such as DNA damage or kinase inhibition. This evidence concerns the gene IFNG and neoplasm.