Worth a notice, LPS treatment has been reported to induce cIAP2 expression in macrophages.18 In addition, cIAP2-deficient mice exhibit profound resistance to LPS-induced sepsis.19 Caspase-3–cIAP2 interaction has previously been reported in various cellular model systems.16, 20, 21 Further, protein–protein interaction between caspase-3 and cIAP2 was confirmed in microglia using an in situ proximity ligation assay (PLA) (Figures 3a and b). The gene discussed is BIRC3; the disease is Sepsis.