However, inhibition of Th1 cytokines using agents such as the TNF-α antagonist, etanercept, to treat experimental hypertension has been equivocal, and consistent with our findings, it suggests that cytokine production may not be the most important or hypertension-specific mechanistic role for T cells during hypertension[6], [23]–[25]. The gene discussed is TNF; the disease is Hypertension.