NFKB1 and cyst: The key findings were that PDTC: (1) attenuated the progression of TKV and cyst volume as determined in serial MRI scans; (2) reduced kidney enlargement, as assessed by ex vivo measurement of the KW:BW ratio; (3) decreased the progression of proteinuria; and (4) did not alter the decline in renal dysfunction, markers of chronic interstitial injury (including monocyte accumulation, renal cell proliferation, and interstitial fibrosis) or significantly alter the expression or activity of NF‐κB proteins at the final time point of the study.