Hypertension may be reduced by food constituents, some of which may act like anti-hypertensive medication e.g. as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, β-blockers, Ca-channel blockers, central α-agonists, direct renin inhibitors, direct vasodilators or diuretics [65]. The gene discussed is REN; the disease is hypertensive disorder.