CGA and metastatic neoplasm: A study by Nolting et al found that GEP-NEN patients affected by liver metastases had significantly higher median CgA values than those without liver metastases (389 ± 38, 103 ng/mL vs. 65 ± 181 ng/mL; P < 0.0001).19 Another study conducted by Walter et al also reported that CgA levels were significantly increased in patients with metastatic disease rather than limited or regional lymph nodes (74% vs. 51%; P = 0.02).20 In agreement with previous findings, our results revealed that CgA levels were increased in patients who were defined as stage IV when compared with those in other stages.