Some previous reports described that VEGF-C and -D stimulated lymphangiogenesis via their receptors and were related to lymphatic metastasis.15–17 A previous in vitro study showed that VEGF-D enhanced the transendothelial migration of sarcoma cells through the human lymphatic endothelial monolayer more than VEGF-C.18 Analyzing the expression of genes related to lymphangiogenesis in cases with the lymphatic histotype may answer this question. Here, VEGFD is linked to sarcoma.