With this system, we noted differences in cytokines and chemokines, like FGF-Basic, IL-15, IL-6, IL-28A, ENA-78 and IP-10 without PBMCs and MIP-1β, IL-28A, MCP-2, and IFN-α with PBMCs between HRV 14 and 16 during infection of calu-3 cells [26]. Here, IFNL2 is linked to infection.