Previously we and others have shown that a variety of cytokines and chemokines were induced by both HRV 14 and/or HRV 16 infection in vitro that include FGF-Basic, chemokines and cytokines like IL-6, IL-15, MCP-2, IP-10, MIP-1β, type I IFN-α, type III IFN-λ2 (IL-28A), and ENA-78 [26], [31], [32]. The gene discussed is IFNL2; the disease is infection.