When the expression level of LRP1 was analyzed at 2 and 4 days following infection with lentivirus carrying LRP1-shRNA in primary cultures of mouse cortical neurons, we found that LRP1 expression was more efficiently suppressed at day 4 compared to day 2 of knockdown (Figs. 1A and B) with no significant effects on cell viability (Fig. 1C). This evidence concerns the gene LRP1 and infection.