In neurons, LRP1 is predominantly expressed in the postsynaptic region [8] and the cell body [9], where it regulates lipid transport [10] and the metabolism of amyloid-β (Aβ) peptides [11], [12] whose accumulation is considered central to the pathogenesis of Alzheimer's disease (AD). This evidence concerns the gene LRP1 and early-onset autosomal dominant Alzheimer disease.