To support this idea it was later shown that TNF-α was indeed capable to induce insulin resistance in lean animals [1]–[3] and that various pro-inflammatory cytokines trigger intracellular pathways such as Nuclear Factor for Kappa light chain in B-cells (NF- κB), IκB kinase-β (IKKβ) and Jun kinase (JNK) which are capable to inhibit the insulin signaling pathway [4]–[8]. This evidence concerns the gene INS and Insulin resistance.